Beta-blockers will block the pulmonary effects of inhaled beta-agonists, and in some cases may exacerbate bronchospasm in patients with reactive airways. Carbetapentane; Phenylephrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. document.write(new Date().getFullYear()) PDR, LLC. Gilteritinib has been associated with QT prolongation. Lapatinib: (Minor) Monitor for evidence of QT prolongation if lapatinib is administered with short-acting beta-agonists. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Rare case reports of QT prolongation have also been described when tamoxifen is used at lower doses. Drugs with a possible risk for QT prolongation that should be used cautiously with halogenated anesthetics include the beta-agonists. Carteolol: (Moderate) Use of a beta-1-selective (cardioselective) beta blocker is recommended whenever possible when this combination of drugs must be used together. The net result of beta2-receptor agonism in the lungs is relaxation of bronchial and tracheal smooth muscles, which in turn relieves bronchospasm, reduces airway resistance, facilitates mucous drainage, and increases vital capacity.Albuterol can also inhibit the degranulation and subsequent release of inflammatory autocoids from mast cells. PDR.net is to be used only as a reference aid. Beta-agonists may cause adverse cardiovascular effects such as QT prolongation, usually at higher doses and/or when associated with hypokalemia. FDA-approved labeling for albuterol 0.083% solution recommends 2.5 mg via oral inhalation 3 to 4 times daily as needed; do not exceed 4 doses/day. Labetalol: (Moderate) Use of a beta-1-selective (cardioselective) beta blocker is recommended whenever possible when this combination of drugs must be used together. Ciprofloxacin: (Minor) Rare cases of QT prolongation and torsade de pointe (TdP) have been reported with ciprofloxacin during post-marketing surveillance. Onset of pulmonary improvement can usually be seen within 30 minutes. The usual dosage for adults and pediatric patients 12 years of age and older is 2.5 mg of albuterol (one unit-of-use vial) administered 3 to 4 times daily by nebulization. Beta-agonists should be administered with caution to patients being treated with drugs known to prolong the QT interval because the action of beta-agonists on the cardiovascular system may be potentiated. Beta-agonists and beta-blockers are pharmacologic opposites, and will counteract each other to some extent when given concomitantly, especially when non-cardioselective beta blockers are used. Lapatinib has been associated with concentration-dependent QT prolongation; ventricular arrhythmias and torsade de pointes (TdP) have been reported in postmarketing experience with lapatinib. In some patients, 90 mcg (1 puff) every 4 hours may be sufficient. Apomorphine: (Minor) Beta-agonists should be used cautiously and with close monitoring with apomorphine. Albuterol solution for nebulization is a prescription medication used for the relief of bronchospasm (narrowing of airways) in patients 2 to 12 years of age with asthma Oral: Albuterol immediate- and extended-release tablets are used for the relief of bronchospasm (narrowing of airways) in adults and children 6 years of age and older with reversible obstructive airway disease (asthma). This risk is generally higher at elevated drugs concentrations of phenothiazines. There is no experience with high exposure or concomitant use with other QT prolonging drugs. Diethylpropion: (Major) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Shake excess water from the mouthpiece and verify that all medication build-up has been rinsed away. Albuterol is used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. [31823] [43674] [44010] [49951] [59350] [64470], There are no randomized clinical studies of use of albuterol during pregnancy. Monitor the patients lung and cardiovascular status closely. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with metronidazole include beta-agonists. Dopamine: (Major) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Albuterol is an effective adjunctive treatment for hyperkalemia; beta2-adrenergic stimulation results in intracellular accumulation of serum potassium due to stimulation of the Na/K ATPase pump, leading to moderate degrees of hypokalemia. Weigh the risks of co-use, and where possible, allow a washout period after discontinuation of the MAOI before instituring beta-agonist treatment or vice-versa. This risk may be more clinically significant with long-acting beta-agonists as compared to short-acting beta-agonists. This risk may be more clinically significant with long-acting beta-agonists as compared to short-acting beta-agonists. Coadminister with caution. Romidepsin: (Minor) Romidepsin has been reported to prolong the QT interval. Guaifenesin; Phenylephrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Beta-agonists can sometimes increase heart rate or have other cardiovascular effects, particularly when used in high doses or if hypokalemia is present. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with citalopram include the beta-agonists. Ivosidenib: (Minor) Coadministration of ivosidenib with short-acting beta-agonists may increase the risk of QT prolongation. QTc prolongation has been observed with the use of efavirenz. 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